Antiarrhythmic effect of the drug Cordarone
Antiarrhythmic effect of the drug Cordarone is carried out due to increase the third phase of the action potential, this occurs thanks to decrease in the flow of potassium through the channels of cell membranes of cardiomyocytes, as well as reduce the automaticity of sinus node (which in turn leads to bradycardia, which does not respond to the impact of atropine). The drug can non-competitively block the alpha-and beta-adrenergic receptors. Cordarone slows the sinoatrial, node, atrial conduction and at the same time does not effect on the idicators of intraventricular conduction. Cordarone increases the refractory period, and also reduces the excitability of the myocardium, slows conduction of excitation, lengthens refractory period of additional atrioventricular pathways.
Cordarone does not create a significant negative inotropic effect. Therapeutic effects can be observed after one week (in some cases – from several days to two weeks) after starting taking the medication
The pharmacokinetic processes
After oral, Cordarone is slowly absorbed from the gastrointestinal tract. Its bioavailability ranges from 30 to 80 percent. Cmax in the blood plasma is achieved after taking a single dose after 3-7 hours. During the first days of treatment Cordarone accumulates practically in all tissues, especially in the liver, fat inclusions, lung, and spleen. The excretion of the drug Cordarone from the body is noticed after a few days. Css can be reached within the range of 1 to several months, depending on the individual patient.
If you need the drug Cordarone, you should not immediately rush to the pharmacy. At present days there is opportunity to buy Cordarone online. You can pay for a purchase Cordarone by using such bank cards as Visa MasterCard and AMEX. Having made some simple steps on the Internet, after a short time you’ll be the owner of this drug – fast delivery does not take long. Technical support competently will answer all questions relating to medications.
Buy cordarone without a prescription
Cordarone should be taken to prevent recurrence of the cases described below. You can order Cordarone online without a prescription, if you have:
Also by using Cordarone are treated such diseases as supraventricular tachycardia (documentary evidences) in order to slow the ventricular rhythm or to restore sinus rhythm at atrial flutter and atrial fibrillation. Cordarone is recommended to patients with coronary heart disease and / or left ventricular dysfunction.
At pregnancy Cordarone is prescribed only for health reasons, as the drug has an effect on the thyroid gland of the fetus. Amiodarone is excreted in breast milk in certain quantities, so the drug should not be used by breastfeeding women during lactation.
Our Technical Support will consult you on all medical matters that relate to the medications. We use the SSL Certificate, which guarantees the security of transmitted data. Please note that in our online drugstore you can buy Cordarone without a prescription. Having ordered Cordarone online, you will free yourself from going to a drugstore.
In which cases Cordarone is contraindicated
In order to avoid negative consequences, is not recommended taking Cordarone in the following cases:
If you have even one of the above cases, it is better to choose for the treatment another drug that will not harm your health. Call our technical support service and qualified specialists will answer all the questions related to the medication Cordarone.